Reduced Blood Serotonin Levels in Chronic Central Serous Chorioretinopathy

Tsutomu Sakai; Hiroshi Tsuneoka

doi:10.1016/j.oret.2016.09.003

Reduced Blood Serotonin Levels in Chronic Central Serous Chorioretinopathy

Ophthalmol Retina. 2017 Mar-Apr;1(2):145-148. doi: 10.1016/j.oret.2016.09.003. Epub 2016 Nov 19.

Authors

Tsutomu Sakai¹, Hiroshi Tsuneoka²

Affiliations

¹ Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan. Electronic address: tstmski@jikei.ac.jp.
² Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.

PMID: 31047270
DOI: 10.1016/j.oret.2016.09.003

Abstract

Purpose: To evaluate blood serotonin (5-hydroxytryptamine [5-HT]) levels in patients with chronic central serous chorioretinopathy (CSC).

Design: A case-controlled retrospective study.

Participants: Forty-nine patients with CSC and 30 age-matched control subjects.

Methods: Blood 5-HT levels were measured using high-performance liquid chromatography.

Main outcome measures: Blood 5-HT levels in patients with acute or chronic CSC were measured at the initial visit and compared with those in controls.

Results: The blood 5-HT level (98.2±27.5 ng/ml) in patients with chronic CSC was significantly lower than those in patients with acute CSC (122.5±23.9 ng/ml, P = 0.0081) and controls (128.5±35.8 ng/ml, P = 0.0013). After adjusting for covariates, patients with decreased blood 5-HT levels were found to be more likely to develop chronic CSC (odds ratio, 0.97; 95% confidence interval, 0.95-0.99; P = 0.009).

Conclusions: These results suggest that serotonin may have a role in chronic CSC pathogenesis and is associated with disease progression.