Stunning and cumulative ischemic dysfunction occur in the left ventricle with coronary balloon occlusion. Glucagon-like peptide (GLP)-1 protects the left ventricle against this dysfunction. This study used a conductance catheter method to evaluate whether the right ventricle (RV) developed similar dysfunction during right coronary artery balloon occlusion and whether GLP-1 was protective. In this study, the RV underwent significant stunning and cumulative ischemic dysfunction with right coronary artery balloon occlusion. However, GLP-1 did not protect the RV against this dysfunction when infused after balloon occlusion.
Keywords: BL, baseline; BO1, first balloon occlusion; BO2, second balloon occlusion; DSHB, Developmental Studies Hybridoma Bank; EDP, end-diastolic pressure; GLP, glucagon-like peptide; GLP-1R, glucagon-like peptide 1 receptor; LV, left ventricular; PCI, percutaneous coronary intervention; PV, pressure–volume; RCA, right coronary artery; RV, right ventricular; Tau, time constant of diastolic relaxation; cardioprotection; dP/dtmax, maximal rate of isovolumetric contraction; dP/dtmin, maximal rate of isovolumetric relaxation; glucagon-like peptide-1; ischemia-reperfusion injury; right ventricle.