Y90 Radioembolization Dosimetry: Concepts for the Interventional Radiologist

Tech Vasc Interv Radiol. 2019 Jun;22(2):100-111. doi: 10.1053/j.tvir.2019.02.011. Epub 2019 Feb 27.

Abstract

Transarterial radioembolization (TARE) with beta particle emitting microspheres via Yttrium-90 decay has become a fundamental component of the contemporary Interventional Oncology practice. TARE continues to advance as a result of increased utilization, clinical study, technological improvements, and evolving applications. To maximize TARE safety and efficacy, a core understanding of dosimetry is essential. The intent of this overview is to provide the reader with a general survey of radiation physics and biology, device differentiation, patient selection, anatomic assessment, activity administration models, and procedural techniques involved with TARE dosimetry.

Keywords: BSA; MIRD; Partition; Radiation Lobectomy; Radiation Segmentectomy; Radioembolization.

Publication types

  • Review

MeSH terms

  • Brachytherapy / methods
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / radiotherapy*
  • Chemoembolization, Therapeutic / methods
  • Embolization, Therapeutic / methods*
  • Humans
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / radiotherapy*
  • Microspheres
  • Organ Specificity
  • Patient Selection
  • Radiation Injuries / etiology
  • Radiation Injuries / prevention & control*
  • Radiobiology / standards*
  • Radiology, Interventional*
  • Yttrium Radioisotopes / therapeutic use*

Substances

  • Yttrium Radioisotopes
  • Yttrium-90