Household coal combustion, indoor air pollutants, and circulating immunologic/inflammatory markers in rural China

J Toxicol Environ Health A. 2019;82(6):411-421. doi: 10.1080/15287394.2019.1614500. Epub 2019 May 13.

Abstract

The study aim was to investigate whether household bituminous ("smoky") coal use and personal exposure to combustion emissions were associated with immunologic/inflammatory marker levels. A cross-sectional study of healthy never-smoking women from rural Xuanwei and Fuyuan, China was conducted, which included 80 smoky coal and 14 anthracite ("smokeless") coal users. Personal exposure to fine particulate matter (PM2.5) and benzo[a]pyrene (BaP) was assessed using portable devices, while 67 circulating plasma immunologic/inflammatory markers were measured using multiplex bead-based assays. Multivariable linear regression models were employed to estimate associations between smoky coal versus smokeless coal use, indoor air pollutants, and immunologic/inflammatory markers. Six markers were altered among smoky coal users compared to smokeless coal, including significantly decreased interferon-inducible T-cell alpha chemoattractant (CXCL11/I-TAC), and increased serum amyloid P component (SAP). CXCL11/I-TAC was previously found to be reduced in workers exposed to high levels of diesel engine exhaust, which exhibits similar constituents as coal combustion emissions. Further, there was evidence that elevated PM2.5 and BaP exposure was associated with significantly diminished levels of the serum amyloid A (SAA); however, the false discovery rates (FDRs) were >0.2 after accounting for multiple comparisons. Inflammatory processes may thus mediate the carcinogenic effects attributed to smoky coal emissions.

Keywords: Smoky coal; combustion; immunologic inflammatory markers; indoor air pollution.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Adult
  • Aged
  • Air Pollution, Indoor / adverse effects*
  • Benzo(a)pyrene / adverse effects*
  • Biomarkers / blood*
  • China
  • Coal / adverse effects*
  • Cooking
  • Cross-Sectional Studies
  • Female
  • Humans
  • Middle Aged
  • Particulate Matter / adverse effects*
  • Rural Population / statistics & numerical data
  • Young Adult

Substances

  • Biomarkers
  • Coal
  • Particulate Matter
  • Benzo(a)pyrene