4-Locus high-resolution HLA allele and haplotype frequencies in admixed population from Nicaragua

Esteban Arrieta-Bolaños; Juan José Madrigal-Sánchez; Jeremy E Stein; María José Moreira-Espinoza; Edel Paredes-Carias; Yondra Vanegas-Padilla; Lizbeth Salazar-Sánchez; J Alejandro Madrigal; Steven G E Marsh; Bronwen E Shaw

doi:10.1016/j.humimm.2019.05.004

4-Locus high-resolution HLA allele and haplotype frequencies in admixed population from Nicaragua

Hum Immunol. 2019 Jul;80(7):417-418. doi: 10.1016/j.humimm.2019.05.004. Epub 2019 May 21.

Affiliations

¹ Institute for Experimental Cellular Therapy, University Hospital, Essen, Germany; Anthony Nolan Research Institute, Royal Free Hospital, London, UK; Centro de Investigaciones en Hematología y Trastornos Afines (CIHATA), Universidad de Costa Rica, San José, Costa Rica. Electronic address: esteban.arrieta-bolanos@uk-essen.de.
² Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica.
³ Anthony Nolan Research Institute, Royal Free Hospital, London, UK.
⁴ Departamento de Ciencias Morfológicas, Universidad Nacional Autónoma de Nicaragua, León, Nicaragua.
⁵ Anthony Nolan Research Institute, Royal Free Hospital, London, UK; UCL Cancer Institute, Royal Free Campus, London, UK.
⁶ Anthony Nolan Research Institute, Royal Free Hospital, London, UK; Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, USA.

PMID: 31122740
DOI: 10.1016/j.humimm.2019.05.004

Abstract

A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 2.26%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Nicaragua Mestizo" and the identifier AFN3610.

Keywords: Admixture; Ancestry; Ethnicity; Frequencies; Hispanic; Human leukocyte antigen; Nicaragua; Population.