Getting to the heart of cardiovascular evolution in humans

Alex Pollen; Bryan J Pavlovic

doi:10.7554/eLife.47807

Getting to the heart of cardiovascular evolution in humans

Elife. 2019 May 28:8:e47807. doi: 10.7554/eLife.47807.

Authors

Alex Pollen^{1

2}, Bryan J Pavlovic^{1

2}

Affiliations

¹ Department of Neurology, University of California, San Francisco, San Francisco, United States.
² The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.

Abstract

Differences in the response of cardiomyocytes to oxygen deprivation in humans and chimpanzees may explain why humans are more prone to certain heart diseases.

Keywords: cardiomyocytes; chimpanzee; evolutionary biology; human; hypoxia; iPSCs.

MeSH terms

Biological Evolution*
Cardiovascular Diseases / genetics
Cardiovascular System / anatomy & histology*
Cardiovascular System / cytology
Genetic Predisposition to Disease
Humans
Models, Biological
Stem Cells / cytology