Novel mouse model of indwelling pleural catheter in mice with malignant pleural effusion

Christopher Merrick; Taylor Sherrill; Nikolaos I Kanellakis; Rachelle Asciak; Georgios T Stathopoulos; Fabien Maldonado; Najib M Rahman; Timothy Blackwell; Ioannis Psallidas

doi:10.1183/23120541.00226-2018

Novel mouse model of indwelling pleural catheter in mice with malignant pleural effusion

ERJ Open Res. 2019 May 28;5(2):00226-2018. doi: 10.1183/23120541.00226-2018. eCollection 2019 Apr.

Authors

Christopher Merrick¹, Taylor Sherrill¹, Nikolaos I Kanellakis^{2

3}, Rachelle Asciak^{2

3}, Georgios T Stathopoulos^{4

5}, Fabien Maldonado¹, Najib M Rahman^{2

3}, Timothy Blackwell¹, Ioannis Psallidas^{2

3

6}

Affiliations

¹ Vanderbilt University Medical Center, Nashville, TN, USA.
² Oxford Centre for Respiratory Medicine, Oxford, UK.
³ Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.
⁴ Comprehensive Pneumology Center and Institute for Lung Biology and Disease, University Hospital, Ludwig-Maximilian University, Helmholtz Center Munich, Member of the German Center for Lung Research, Munich, Germany.
⁵ Laboratory for Molecular Respiratory Carcinogenesis, Dept of Physiology, Faculty of Medicine, University of Patras, Patras, Greece.
⁶ Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.

Abstract

This novel mouse model mimics malignant pleural effusion drainage using an indwelling pleural catheter in humans, and provides direct access to the pleural space potentially enabling the testing of intrapleural therapies in the treatment of MPE. bit.ly/2W2kzO0.