Objective: To study the correlation between the prognosis of sudden deafness and laboratory indicators, and to provide a theoretical basis for clinical evaluation of prognosis and selection of appropriate interventions.Method: A retrospective analysis of 123 cases of total deafness was conducted(all frequencies decreased with 250-8 000 Hz average hearing threshold ≥ 81 dB HL). All patients admitted to the hospital received laboratory test within 24 hours and underwent a unified treatment: alprostadil + mecobalamin + citicoline sodium phosphate + Ginkgo biloba extract + batroxobin + methylprednisolone (patients with hypertension or diabetes were given retro-auricular injection). After 2 weeks of comprehensive treatment, the pure tone audiometry was reviewed and the clinical efficacy was evaluated. According to the prognosis, the patients were divided into the healing group, the marked effective group, the effective group and the ineffective group. The laboratory indicators included: white blood cell count, neutrophil percentage, neutrophil lymphocyte ratio(NHR), erythrocyte sedimentation rate, blood lipid, red blood cell count, hemoglobin(Hb), plasma fibrinogen content(FIB). Result: There were no significant differences in white blood cell count, neutrophil percentage, NHR, erythrocyte sedimentation rate, blood lipid index and red blood cell count between different prognosis groups(all P>0.05). The differences of FIB and Hb were statistically significant(P<0.05). The overall prognosis was negatively correlated with FIB and positively correlated with Hb. Patients with vertigo had a worse prognosis and a higher plasma FIB level than those without vertigo(P<0.05), but there was no significant difference of Hb between patients with and without vertigo(P>0.05). Conclusion: FIB and Hb can be used as correlative indexes to evaluate the prognosis of patients with sudden deafness, and the effects of vertigo and other associated symptoms on the prognosis should be comprehensively analyzed. .
目的： 研究突发性聋全聋型患者预后与实验室指标的相关性，为临床评估患者预后及采取合适的干预措施提供理论依据。方法： 回顾性分析123例突发性聋全聋型患者（所有频率听力均下降，250～8 000 Hz平均听阈≥ 81 dB HL）的临床资料，患者24 h内均空腹采血，采用统一的治疗方案［前列地尔＋弥可保＋胞磷胆碱磷酸钠＋银杏叶提取物＋巴曲酶＋甲泼尼龙（高血压、糖尿病患者改用耳后局部注射）］进行综合治疗，治疗2周后复查纯音测听评价其临床疗效。根据预后分为痊愈组、显效组、有效组和无效组，分析患者预后与实验室各指标［白细胞计数、中性粒细胞百分率、中性粒淋巴细胞比值（NHR）、血沉、血脂、红细胞计数、血红蛋白（Hb）、血浆纤维蛋白原含量（FIB）］的相关性。结果： 不同预后组间白细胞计数、中性粒细胞百分率、NHR、血沉、血脂、红细胞计数差异均无统计学意义（P>0.05）；FIB、Hb差异有统计学意义（均P<0.05），全聋型患者预后与FIB呈负相关，与Hb呈正相关。伴眩晕者较不伴眩晕者预后差，且伴眩晕者血浆FIB较不伴眩晕者高，差异有统计学意义（P<0.05），但与Hb差异无统计学意义（P>0.05）。结论： 血浆FIB和Hb可作为评估突发性聋全聋型患者预后的相关性指标，同时需要综合分析其眩晕等伴随症状对预后的影响。.
Keywords: deafness，sudden; fibrinogen; hemoglobin; prognosis; vertigo; fibrinogen.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.