Successful kidney transplantation in a small child with end-stage renal disease due to angiotensin receptor blocker fetopathy and atretic inferior vena cava

Pediatr Transplant. 2019 Sep;23(6):e13497. doi: 10.1111/petr.13497. Epub 2019 Jun 18.

Abstract

Kidney transplantation is the treatment of choice in pediatric patients with end-stage renal disease. This population presents technical challenges particularly in those less than 20 kg due to anomalous anatomy, vascular access issues prior to transplantation, and a generally small size for age. Standard allograft outflow is usually achieved utilizing the iliac veins or IVC. When use of the iliocaval system is not feasible, alternative anastomosis must be considered. Herein, we report a case of a pediatric kidney transplantation where successful allograft outflow was achieved using the SMV when he was found to have an atretic IVC intraoperatively. In this setting, use of the portal system was required to achieve adequate allograft outflow. We created a donor iliac graft for added length to anastomose the renal vein with the SMV. In the setting of IVC occlusion with poor drainage, we utilized a patent vessel with larger caliber for outflow to reduce the risk of high venous pressures, allograft failure, venous rotation, and thrombosis. We conclude that the SMV may serve as an alternative outflow tract in the small pediatric patient and provides the vessel caliber needed to reduce the risks of complications.

Keywords: inferior vena cava; kidney transplantation; pediatric; superior mesenteric vein; surgical technique; thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Allografts
  • Anastomosis, Surgical
  • Angiotensin Receptor Antagonists / adverse effects*
  • Aorta / pathology
  • Child, Preschool
  • Humans
  • Iliac Vein / surgery
  • Imidazoles / adverse effects
  • Kidney / surgery
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation*
  • Male
  • Pediatrics
  • Postoperative Period
  • Renal Veins / surgery
  • Tetrazoles / adverse effects
  • Thrombosis / surgery
  • Vascular Grafting
  • Vena Cava, Inferior / pathology
  • Vena Cava, Inferior / surgery*
  • Venous Thrombosis / complications

Substances

  • Angiotensin Receptor Antagonists
  • Imidazoles
  • Tetrazoles
  • olmesartan