Increased extracellular maspin levels after mechanical compression in vitro or allergen challenge in vivo

J Allergy Clin Immunol. 2019 Oct;144(4):1116-1118.e4. doi: 10.1016/j.jaci.2019.06.006. Epub 2019 Jun 19.

Abstract

Maspin secretion from bronchial epithelial cells is substantially elevated by mechanical compression and in BAL fluid of patients with asthma following an allergen challenge, suggesting a potential role of maspin in asthma pathophysiology.

Publication types

  • Letter

MeSH terms

  • Airway Remodeling / immunology*
  • Allergens / immunology
  • Animals
  • Asthma / immunology*
  • Asthma / physiopathology
  • Cells, Cultured
  • Humans
  • Mice
  • Physical Stimulation
  • Respiratory Mucosa / immunology*
  • Respiratory Mucosa / metabolism
  • Serpins / immunology*

Substances

  • Allergens
  • SERPIN-B5
  • Serpins