Cold Atmospheric Plasma as an Adjunct to Immunotherapy for Glioblastoma Multiforme

Neil D Almeida; Andrea L Klein; Elizabeth A Hogan; Samantha J Terhaar; Jayanidhi Kedda; Prayerna Uppal; Kenneth Sack; Michael Keidar; Jonathan H Sherman

doi:10.1016/j.wneu.2019.06.209

Cold Atmospheric Plasma as an Adjunct to Immunotherapy for Glioblastoma Multiforme

World Neurosurg. 2019 Oct:130:369-376. doi: 10.1016/j.wneu.2019.06.209. Epub 2019 Jul 5.

Authors

Neil D Almeida¹, Andrea L Klein², Elizabeth A Hogan³, Samantha J Terhaar¹, Jayanidhi Kedda¹, Prayerna Uppal¹, Kenneth Sack⁴, Michael Keidar⁵, Jonathan H Sherman⁴

Affiliations

¹ The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA.
² The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, District of Columbia, USA.
³ Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA. Electronic address: eahogan13@gmail.com.
⁴ Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA.
⁵ Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, District of Columbia, USA.

PMID: 31284051
DOI: 10.1016/j.wneu.2019.06.209

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in adults. GBM carries a dismal prognosis because of its proliferative, invasive, and angiogenic capabilities and because of its ability to downregulate the immune system. Immune-based therapies under investigation for GBM have been unsuccessful in vivo because of this downregulation. Cold atmospheric plasma (CAP) is a high-energy state of matter that can be applied directly or indirectly to tumor tissue to serve as an adjunct to immunotherapy in the treatment of GBM because it upregulates the immune system by the induction of reactive oxygen species. CAP has the potential to improve the efficacy of existing and investigative immunotherapies for GBM.

Keywords: Cold atmospheric plasma; Glioblastoma multiforme; Immunotherapy.

Publication types

Review

MeSH terms

Brain Neoplasms / immunology
Brain Neoplasms / therapy*
Combined Modality Therapy
Forecasting
Glioblastoma / immunology
Glioblastoma / therapy*
Humans
Immunity, Cellular / immunology
Immunotherapy / methods*
Immunotherapy / trends
Plasma Gases / therapeutic use*
Tumor Escape / immunology

Substances

Plasma Gases