Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

Adam J de Smith; Kyle M Walsh; Libby M Morimoto; Stephen S Francis; Helen M Hansen; Soyoung Jeon; Semira Gonseth; Minhui Chen; Hanxiao Sun; Sandra Luna-Fineman; Federico Antillón; Verónica Girón; Alice Y Kang; Ivan Smirnov; Xiaorong Shao; Todd P Whitehead; Lisa F Barcellos; Kent W Jolly; Jasmine Healy; Caroline Laverdière; Daniel Sinnett; Jeffrey W Taub; Jillian M Birch; Pamela D Thompson; Maria S Pombo-de-Oliveira; Logan G Spector; Andrew T DeWan; Beth A Mueller; Charleston Chiang; Catherine Metayer; Xiaomei Ma; Joseph L Wiemels

doi:10.1038/s41375-019-0514-9

Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

Leukemia. 2019 Nov;33(11):2746-2751. doi: 10.1038/s41375-019-0514-9. Epub 2019 Jul 11.

Authors

Adam J de Smith¹, Kyle M Walsh^{2

3

4}, Libby M Morimoto⁵, Stephen S Francis^{4

6}, Helen M Hansen⁷, Soyoung Jeon⁸, Semira Gonseth⁹, Minhui Chen⁸, Hanxiao Sun⁸, Sandra Luna-Fineman¹⁰, Federico Antillón¹¹, Verónica Girón¹¹, Alice Y Kang⁵, Ivan Smirnov⁷, Xiaorong Shao⁵, Todd P Whitehead⁵, Lisa F Barcellos⁵, Kent W Jolly¹², Jasmine Healy¹³, Caroline Laverdière¹³, Daniel Sinnett¹³, Jeffrey W Taub¹⁴, Jillian M Birch¹⁵, Pamela D Thompson¹⁵, Maria S Pombo-de-Oliveira¹⁶, Logan G Spector¹⁷, Andrew T DeWan¹⁸, Beth A Mueller¹⁹, Charleston Chiang⁸, Catherine Metayer⁵, Xiaomei Ma¹⁸, Joseph L Wiemels^{8

4}

Affiliations

¹ Center for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA. desmith@usc.edu.
² Department of Neurosurgery, Duke University, Durham, NC, USA.
³ Duke Cancer Institute, Duke University, Durham, NC, USA.
⁴ Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
⁵ School of Public Health, University of California Berkeley, Berkeley, CA, USA.
⁶ Division of Epidemiology, School of Community Health Sciences, University of Nevada, Reno, NV, USA.
⁷ Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
⁸ Center for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
⁹ Division of Chronic Disease, Institute of Social and Preventive Medicine, Lausanne, Switzerland.
¹⁰ Children's Hospital Colorado and University of Colorado, Denver, CO, USA.
¹¹ Unidad Nacional de Oncología Pediatrica; and Universidad Francisco Marroquín, Guatemala City, Guatemala.
¹² Department of Pediatrics, Kaiser Permanente, Roseville, CA, USA.
¹³ Sainte-Justine University Health Center, Montreal, QC, Canada.
¹⁴ Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA.
¹⁵ University of Manchester, Manchester, UK.
¹⁶ Instituto Nacional de Cancer, Rio de Janeiro, Brazil.
¹⁷ Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
¹⁸ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
¹⁹ Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

No abstract available

Publication types

Letter
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
California / epidemiology
California / ethnology
Case-Control Studies
Child
Child, Preschool
Chromosomes, Human, Pair 21 / genetics
Down Syndrome / complications
Down Syndrome / ethnology
Down Syndrome / genetics*
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Guatemala / epidemiology
Guatemala / ethnology
Haplotypes
Hispanic or Latino
Humans
Infant
Infant, Newborn
Male
Polymorphism, Single Nucleotide*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma / ethnology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Principal Component Analysis
Risk Factors
Transcriptional Regulator ERG / genetics

Substances

ERG protein, human
Transcriptional Regulator ERG

Publication types

MeSH terms

Substances

Grants and funding