Histiocytosis X Langerhans cells react with antiinterleukin-2 receptor monoclonal antibody

S Barbey; P Gane; O Le Pelletier; C Nezelof

doi:10.3109/15513818709161420

Histiocytosis X Langerhans cells react with antiinterleukin-2 receptor monoclonal antibody

Pediatr Pathol. 1987;7(5-6):569-74. doi: 10.3109/15513818709161420.

Authors

S Barbey¹, P Gane, O Le Pelletier, C Nezelof

Affiliation

¹ Groupe de Pathologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France.

PMID: 3130619
DOI: 10.3109/15513818709161420

Abstract

Immunohistochemical study of 7 cases of histiocytosis X (HX) and of histologically normal skin shows that HX Langerhans cells react with Bl.49.9 monoclonal antibody which recognizes the Interleukin-2 receptor, whereas normal skin Langerhans cells do not. This reactivity suggest activation of HX Langerhans cells.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal / immunology
Fluorescent Antibody Technique
Histiocytosis, Langerhans-Cell / immunology*
Histiocytosis, Langerhans-Cell / pathology
Humans
Interleukin-2*
Langerhans Cells / immunology*
Receptors, Immunologic / analysis*
Receptors, Interleukin-2
Skin

Substances

Antibodies, Monoclonal
Interleukin-2
Receptors, Immunologic
Receptors, Interleukin-2