Bimetallic Cu/Pd-catalyzed three-component azide-alkyne cycloaddition/isocyanide insertion: synthesis of fully decorated tricyclic triazoles

Org Biomol Chem. 2019 Aug 7;17(31):7320-7324. doi: 10.1039/c9ob01175g.

Abstract

The construction of fully decorated 1,2,3-triazole-fused 5-, 6- and 7-membered rings has been disclosed via a bimetallic relay-catalyzed cascade process combining azide-alkyne cycloaddition, C(sp2)-H functionalization of intermediary 1,2,3-triazoles and isocyanide insertion. The salient features of this methodology include simple starting materials, reduced synthetic steps, good substrate scope and high efficiency.

Publication types

  • Research Support, Non-U.S. Gov't