A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes

Rocío Amoretti-Villa; Mélanie Rogier; Isabelle Robert; Vincent Heyer; Bernardo Reina-San-Martin

doi:10.1038/s41423-019-0267-4

A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes

Cell Mol Immunol. 2019 Nov;16(11):887-889. doi: 10.1038/s41423-019-0267-4. Epub 2019 Aug 5.

Authors

Rocío Amoretti-Villa^{1

2

3

4}, Mélanie Rogier^{1

2

3

4}, Isabelle Robert^{1

2

3

4}, Vincent Heyer^{1

2

3

4}, Bernardo Reina-San-Martin^{5

6

7

8}

Affiliations

¹ Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
² Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Illkirch, France.
³ Centre National de la Recherche Scientifique (CNRS), UMR7104, Illkirch, France.
⁴ Université de Strasbourg, Illkirch, France.
⁵ Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France. reinab@igbmc.fr.
⁶ Institut National de la Santé et de la Recherche Médicale (INSERM), U1258, Illkirch, France. reinab@igbmc.fr.
⁷ Centre National de la Recherche Scientifique (CNRS), UMR7104, Illkirch, France. reinab@igbmc.fr.
⁸ Université de Strasbourg, Illkirch, France. reinab@igbmc.fr.

No abstract available

MeSH terms

Animals
Genetic Loci / immunology*
Immunoglobulin Class Switching / immunology*
Immunoglobulin Heavy Chains / genetics
Immunoglobulin Heavy Chains / immunology*
Mice
Mice, Knockout
Recombination, Genetic / immunology*
Transcription, Genetic / genetics
Transcription, Genetic / immunology*

Substances

Immunoglobulin Heavy Chains

Grants and funding

ANR-10-IDEX-0002-02/Agence Nationale de la Recherche (French National Research Agency)/International