Peripheral Blood T-Cell Fitness Is Diminished in Patients With Pancreatic Carcinoma but Can Be Improved With Homeostatic Cytokines

J Xu; H Sai; Y Li; A C Jordan; S E McGettigan; J-H Chen; F Bedoya; J A Fraietta; W L Gladney; J Joseph Melenhorst; G L Beatty

doi:10.1016/j.jcmgh.2019.07.008

Peripheral Blood T-Cell Fitness Is Diminished in Patients With Pancreatic Carcinoma but Can Be Improved With Homeostatic Cytokines

Cell Mol Gastroenterol Hepatol. 2019;8(4):656-658.e6. doi: 10.1016/j.jcmgh.2019.07.008. Epub 2019 Aug 6.

Authors

J Xu¹, H Sai¹, Y Li², A C Jordan², S E McGettigan¹, J-H Chen³, F Bedoya¹, J A Fraietta⁴, W L Gladney⁵, J Joseph Melenhorst⁶, G L Beatty⁷

Affiliations

¹ Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.
² Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
³ Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
⁴ Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
⁵ Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
⁶ Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: mej@pennmedicine.upenn.edu.
⁷ Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: gregory.beatty@pennmedicine.upenn.edu.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes / metabolism
CD8-Positive T-Lymphocytes / metabolism
Carcinoma, Pancreatic Ductal / immunology*
Carcinoma, Pancreatic Ductal / physiopathology*
Cell Proliferation / physiology
Cytokines
Female
Gene Expression / genetics
Homeostasis
Humans
Immunotherapy / methods
Interleukin-15 / analysis
Interleukin-7 / analysis
Male
Pancreatic Neoplasms / immunology
T-Lymphocytes / immunology*
T-Lymphocytes / physiology
Transcriptome / genetics

Substances

Cytokines
IL7 protein, human
Interleukin-15
Interleukin-7

Publication types

MeSH terms

Substances

Grants and funding