Allergic Bronchopulmonary Mycosis Caused by Schizophyllum commune: A Special Interest in Positive Culture of Other Basidiomycetes Fungi

Intern Med. 2019 Dec 15;58(24):3569-3572. doi: 10.2169/internalmedicine.2694-19. Epub 2019 Aug 21.

Abstract

A 42-year-old man with asthma presented in 2007 with chest infiltration and productive cough. Pycnoporus sanguineus and Perenniporia tephropora were repeatedly isolated from sputum and bronchial washing fluids. Because we lacked immunologic evidence, we could not diagnose him with allergic bronchopulmonary mycosis (ABPM) due to these basidiomycetous fungi. At that time, serum-specific IgE and IgG against Schizophyllum commune findings were negative. Inhaled beclomethasone/salmeterol improved his condition. Seven years later, mucous plugs obtained via bronchoscopy at a relapse were compatible with allergic mucin. Because S. commune was isolated from mucous plugs and serum-specific IgG against S. commune turned positive, we diagnosed the patient with ABPM due to S. commune.

Keywords: Perenniporia tephropora; Pycnoporus sanguineus; Schizophyllum commune; allergic bronchopulmonary mycosis; mucoid impaction of bronchi.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Asthma / complications
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases, Fungal / immunology
  • Lung Diseases, Fungal / microbiology*
  • Male
  • Radiography, Thoracic
  • Respiratory Hypersensitivity / microbiology*
  • Schizophyllum / isolation & purification*
  • Sputum / microbiology
  • Tomography, X-Ray Computed