Dataset of allele, genotype and haplotype frequencies of four LIN28B gene polymorphisms analyzed for association with age at menarche in Russian women

Irina Ponomarenko; Evgeny Reshetnikov; Oleg Golovchenko; Alexey Polonikov; Irina Verzilina; Inna Sorokina; Inna Aristova; Anna Yermachenko; Volodymyr Dvornyk; Mikhail Churnosov

doi:10.1016/j.dib.2019.104323

Dataset of allele, genotype and haplotype frequencies of four LIN28B gene polymorphisms analyzed for association with age at menarche in Russian women

Data Brief. 2019 Jul 30:25:104323. doi: 10.1016/j.dib.2019.104323. eCollection 2019 Aug.

Affiliations

¹ Department of Medical Biological Disciplines, Belgorod State University, 308015, Belgorod, Russia.
² Department of Obstetrics and Gynecology, Belgorod State University, 308015, Belgorod, Russia.
³ Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, 305041, Kursk, Russia.
⁴ Department of Social Epidemiology, Pierre Louis Institute of Epidemiology and Public Health, 75571, Paris, France.
⁵ Sorbonne Universités, 75320, Paris, France.
⁶ Department of Life Sciences, College of Science and General Studies, Alfaisal University, 11533, Riyadh, Saudi Arabia.

Abstract

In this paper, we present the allele, genotype and haplotype frequencies of 4 single nucleotide polymorphisms (SNPs) in LIN28B gene (rs4946651, rs7759938, rs314280, rs314276) in a sample of Russian women. These SNPs had been previously identified to be associated with age at menarche in genome-wide association studies (GWAS). The information about age at menarche was obtained using the questionnaire. The frequencies of alleles, genotypes and haplotypes of four SNPs were classified in 3 groups: the whole sample, individuals with the early age at menarche (<12 years), and those with the average age at menarche (12-14 years).

Keywords: Age at menarche; LIN28B gene; Single nucleotide polymorphism.