Advances in tissue engineering of nanocellulose-based scaffolds: A review

Huize Luo; Ruitao Cha; Juanjuan Li; Wenshuai Hao; Yan Zhang; Fengshan Zhou

doi:10.1016/j.carbpol.2019.115144

Advances in tissue engineering of nanocellulose-based scaffolds: A review

Carbohydr Polym. 2019 Nov 15:224:115144. doi: 10.1016/j.carbpol.2019.115144. Epub 2019 Jul 29.

Authors

Huize Luo¹, Ruitao Cha², Juanjuan Li³, Wenshuai Hao⁴, Yan Zhang⁵, Fengshan Zhou⁶

Affiliations

¹ Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China; Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China. Electronic address: hzluo@cugb.edu.cn.
² Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China. Electronic address: chart@nanoctr.cn.
³ Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China; Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China. Electronic address: lijuanjuan133@126.com.
⁴ Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China; Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China. Electronic address: haows@cugb.edu.cn.
⁵ Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100032, China. Electronic address: waikezhangyan@126.com.
⁶ Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China. Electronic address: zhoufs@cugb.edu.cn.

PMID: 31472870
DOI: 10.1016/j.carbpol.2019.115144

Abstract

Scaffolds based on nanocellulose (NC) have crucial applications in tissue engineering (TE) owing to the biocompatibility, water absorption, water retention, optical transparency, and chemo-mechanical properties. In this review, we summarize the scaffolds based on nanocellulose, including nanocrystalline cellulose and nanofibrillated cellulose. We compare four representative methods to prepare NC-based scaffolds, containing electrospinning, freeze-drying, 3D printing, and solvent casting. We outline the characteristics of scaffolds obtained by different methods. Our focus is on the applications of NC-based scaffolds to repair, improve or replace damaged tissues and organs, including skin, blood vessel, nerve, skeletal muscle, heart, liver, and ophthalmology. NC-based scaffolds are attractive materials for regeneration of different tissues and organs due to the remarkable features. Finally, we propose the challenges and potentials of NC-based TE scaffolds.

Keywords: Nanocrystalline cellulose; Nanofibrillated cellulose; Scaffold; Tissue engineering.

Publication types

Review

MeSH terms

Cellulose / chemistry*
Cellulose / pharmacology
Humans
Nanostructures / chemistry*
Tissue Engineering / methods*
Tissue Scaffolds / chemistry*

Substances

Cellulose