L-phenylalanine mustard-dianhydrogalactitol and hyponatremia

Pediatr Hematol Oncol. 1986;3(3):287-91. doi: 10.3109/08880018609031229.

Abstract

The incidence of hyponatremia in 34 patients following administration of high-dose L-phenylalanine mustard (L-PAM) and dianhydrogalactitol (DAG) was determined. Two consecutive daily levels of 133 mEq/l or less were observed in 12 patients. These episodes coincided with the advent of diarrhea about 10-12 days after drug administration. The hyponatremia was not due to the syndrome of inappropriate antidiuretic hormone secretion.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Diagnosis, Differential
  • Dianhydrogalactitol / adverse effects*
  • Diarrhea / chemically induced
  • Diarrhea / complications*
  • Humans
  • Hyponatremia / diagnosis
  • Hyponatremia / etiology*
  • Inappropriate ADH Syndrome / chemically induced*
  • Inappropriate ADH Syndrome / diagnosis
  • Melphalan / adverse effects*
  • Nervous System Neoplasms / complications
  • Nervous System Neoplasms / drug therapy
  • Neuroblastoma / complications
  • Neuroblastoma / drug therapy
  • Prospective Studies

Substances

  • Dianhydrogalactitol
  • Melphalan