Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

Bo Kyung Koo; Jung Nam An; Sae Kyung Joo; Donghee Kim; Seonhwa Lee; Jeong Mo Bae; Jeong Hwan Park; Jung Ho Kim; Mee Soo Chang; Won Kim

doi:10.1016/j.cgh.2019.09.017

Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

Clin Gastroenterol Hepatol. 2020 Nov;18(12):2837-2839.e2. doi: 10.1016/j.cgh.2019.09.017. Epub 2019 Sep 20.

Authors

Bo Kyung Koo¹, Jung Nam An², Sae Kyung Joo³, Donghee Kim⁴, Seonhwa Lee⁵, Jeong Mo Bae⁶, Jeong Hwan Park⁶, Jung Ho Kim⁶, Mee Soo Chang⁶, Won Kim⁷

Affiliations

¹ Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
² Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
³ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
⁴ Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
⁵ Department of Bio-convergence Engineering, Korea University, Seoul, Korea.
⁶ Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
⁷ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea. Electronic address: drwon1@snu.ac.kr.

PMID: 31546054
DOI: 10.1016/j.cgh.2019.09.017

Abstract

Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share risk factors, and recent meta-analysis confirmed that NAFLD is an independent risk factor for incident CKD.¹ Genetic variants associated with NAFLD, such as patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409² and transmembrane 6 superfamily member 2 (TM6SF2) rs5854292,² have been reported to be associated with renal function in NAFLD subjects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acyltransferases / genetics
Biopsy
Genetic Predisposition to Disease
Humans
Lipase / genetics
Liver
Membrane Proteins / genetics
Non-alcoholic Fatty Liver Disease* / genetics
Polymorphism, Single Nucleotide
Renal Insufficiency, Chronic* / genetics

Substances

Membrane Proteins
Acyltransferases
MBOAT7 protein, human
Lipase