Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature

Ashley C Eason; Silvia T Bunting; Jess F Peterson; Debra Saxe; Himalee S Sabnis

doi:10.1155/2019/4198415

Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature

Case Rep Hematol. 2019 Sep 8:2019:4198415. doi: 10.1155/2019/4198415. eCollection 2019.

Authors

Ashley C Eason¹, Silvia T Bunting², Jess F Peterson³, Debra Saxe⁴, Himalee S Sabnis¹

Affiliations

¹ Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA, USA.
² Department of Pathology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
³ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
⁴ Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.

Abstract

Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML.

Publication types

Case Reports