Functionalization of activated methylene C-H bonds with nitroarenes and sulfur for the synthesis of thioamides

Org Biomol Chem. 2019 Oct 28;17(40):8987-8991. doi: 10.1039/c9ob01751h. Epub 2019 Oct 4.

Abstract

We report a method to obtain arylthioamides by the functionalization of sp3 C-H bonds in phenylacetic acids and benzyl alcohols. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allow for a rapid synthesis of thioamides from simple, commercial substrates.

Publication types

  • Research Support, Non-U.S. Gov't