Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01

Chem Biodivers. 2019 Dec;16(12):e1900471. doi: 10.1002/cbdv.201900471. Epub 2019 Nov 12.

Abstract

One natural p-terphenyl glycoside, gliocladinin C, and two furano-polyene derivatives, chaetominins A and B, were isolated from potato endophytic fungus Chaetomium subaffine. The absolute configurations of these compounds were elucidated by HR-ESI-MS, NMR, the DP4+ probabilities and electronic circular dichroism (ECD) spectra. Furthermore, gliocladinin C and chaetominin A showed cytotoxic activity against two selected human tumor cell lines (Hep-2 and HepG-2).

Keywords: DP4+ probabilities; ECD, cytotoxicity; endophytic fungus; p-terphenyl.

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chaetomium / chemistry
  • Chaetomium / metabolism*
  • Circular Dichroism
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Terphenyl Compounds / chemistry*
  • Terphenyl Compounds / pharmacology

Substances

  • Antineoplastic Agents
  • Terphenyl Compounds