Partial duplication of chromosome 1q preceding the development of an L3 lymphoblastic leukemia with t(8;14), secondary to treatment for Hodgkin's disease

Eur J Haematol. 1988 Mar;40(3):193-7. doi: 10.1111/j.1600-0609.1988.tb00823.x.

Abstract

We report on a case of secondary lymphoblastic leukemia L3 in a patient treated with chemo- radiotherapy for a previous Hodgkin's disease. The typical chromosome translocation t(8;14) was found in association with a translocation t(9;19) and a marker chromosome 1, dup(1q). The same marker chromosome had been detected in a few cells of peripheral blood 2 years before the onset of the acute leukemia and may represent a proliferation-associated change, responsible for the initiation of the process of leukemogenesis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromosome Banding
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 8*
  • Hodgkin Disease / complications
  • Hodgkin Disease / therapy*
  • Humans
  • Karyotyping
  • Leukemia, Lymphoid / etiology
  • Leukemia, Lymphoid / genetics*
  • Male
  • Translocation, Genetic*