5q- syndrome terminating in acute myeloid leukemia. Karyotype evolution and immunologic characterization of blast cells

E Donti; A Tabilio; G V Donti; C Mecucci; A Carotti; F Grignani; M F Martelli

doi:10.1016/0165-4608(88)90282-8

5q- syndrome terminating in acute myeloid leukemia. Karyotype evolution and immunologic characterization of blast cells

Cancer Genet Cytogenet. 1988 Jun;32(2):205-9. doi: 10.1016/0165-4608(88)90282-8.

Authors

E Donti¹, A Tabilio, G V Donti, C Mecucci, A Carotti, F Grignani, M F Martelli

Affiliation

¹ 1st Institute of Internal Medicine, School of Medicine, Perugia University, Italy.

PMID: 3163260
DOI: 10.1016/0165-4608(88)90282-8

Abstract

We report a case of 5q- syndrome that progressed to acute nonlymphocytic leukemia after 9 years of clinically and morphologically stable disease. The transition from the chronic to the leukemic phase was characterized by the appearance of an additional cytogenetic anomaly [inv(2)] in the cell carrying the 5q-, together with the expansion of a clone showing an apparently normal karyotype.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Refractory / complications
Anemia, Refractory / genetics*
Anemia, Refractory / pathology
Antibodies, Monoclonal
Blast Crisis / genetics*
Blast Crisis / immunology
Blast Crisis / pathology
Chromosome Deletion*
Chromosomes, Human, Pair 5*
Humans
Karyotyping
Leukemia, Myeloid, Acute / etiology
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Male
Middle Aged
Syndrome

Substances

Antibodies, Monoclonal