Stroke detection with 3 different PET tracers

Ayca Dundar; Michael S Bold; Busranur Agac; Ayse Tuba Kendi; Saul N Friedman

doi:10.1016/j.radcr.2019.09.005

Stroke detection with 3 different PET tracers

Radiol Case Rep. 2019 Oct 1;14(11):1447-1451. doi: 10.1016/j.radcr.2019.09.005. eCollection 2019 Nov.

Authors

Ayca Dundar¹, Michael S Bold¹, Busranur Agac², Ayse Tuba Kendi¹, Saul N Friedman^{1

3}

Affiliations

¹ Department of Radiology, Mayo Clinic, 150 3rd Street SW, Rochester, MN 55905, USA.
² Department of Neurology, Mayo Clinic, Rochester, MN.
³ Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO.

Abstract

Stroke is a common cause of patient morbidity and mortality, being the fifth leading cause of death in the United States. Positron emission tomography (PET) is a proven tool for oncology patients, and may have utility in patients with stroke. We demonstrate findings of stroke incidentally detected on oncologic PET/CTs using ¹⁸F-FDG, ¹¹C-Choline, and ⁶⁸Ga-DOTATATE radiotracers. Specifically, focal ¹¹C-Choline or ⁶⁸Ga-DOTATATE uptakes localized in areas of MRI confirmed ischemia, and paradoxically increased ¹⁸F-FDG activity was visualized surrounding a region of hemorrhage, in different patients. These cases demonstrate that PET may have utility in evaluating patients with stroke based on flow dynamics, metabolic activity, and receptor expression.

Keywords: 11C-Choline; 18F-FDG; 68Ga-DOTATATE; PET; Stroke.

Publication types

Case Reports