MR imaging of a group I case of Hallervorden-Spatz disease

J Comput Assist Tomogr. 1988 Sep-Oct;12(5):851-3. doi: 10.1097/00004728-198809010-00023.

Abstract

Magnetic resonance (MR) imaging of a case of Hallervorden-Spatz disease (HSD) using a 1.5 T system is described. The patient showed progressive spastic diplegia with equinovarus deformity of the feet, dystonic postural movements, dysarthria, dysphagia, mental deterioration, optic nerve atrophy, and peripheral neuropathy. These clinical features were compatible with HSD. Symmetrical, decreased signal intensity was seen on both proton density weighted and T2-weighted spin echo images in the globus pallidus as well as in the substantia nigra (Group I). This MR finding suggests an increased iron deposition in these subcortical nuclei, which is characteristic of HSD. The characteristic MR imaging, together with the relevant clinical features, was considered to be useful for establishing the diagnosis of HSD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basal Ganglia Diseases / diagnosis*
  • Globus Pallidus / metabolism
  • Globus Pallidus / pathology
  • Humans
  • Iron / metabolism
  • Magnetic Resonance Imaging*
  • Male
  • Pantothenate Kinase-Associated Neurodegeneration / diagnosis*
  • Substantia Nigra / metabolism
  • Substantia Nigra / pathology

Substances

  • Iron