CD34+ acute myeloid leukemia cells with low levels of reactive oxygen species show increased expression of stemness genes and can be targeted by the BCL2 inhibitor venetoclax

Haematologica. 2020 Aug;105(8):e399-e403. doi: 10.3324/haematol.2019.229997. Epub 2019 Nov 14.
No abstract available

Publication types

  • Letter

MeSH terms

  • Bridged Bicyclo Compounds, Heterocyclic* / pharmacology
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / genetics
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Reactive Oxygen Species
  • Sulfonamides

Substances

  • BCL2 protein, human
  • Bridged Bicyclo Compounds, Heterocyclic
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Sulfonamides
  • venetoclax