Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

Philipp Sievers; Daniel Schrimpf; Damian Stichel; David E Reuss; Martin Hasselblatt; Christian Hagel; Ori Staszewski; Jürgen Hench; Stephan Frank; Sebastian Brandner; Andrey Korshunov; Wolfgang Wick; Stefan M Pfister; Guido Reifenberger; Andreas von Deimling; Felix Sahm; David T W Jones

doi:10.1007/s00401-019-02097-7

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

Acta Neuropathol. 2020 Feb;139(2):403-406. doi: 10.1007/s00401-019-02097-7. Epub 2019 Nov 15.

Authors

Philipp Sievers^{1

2}, Daniel Schrimpf^{1

2}, Damian Stichel^{1

2}, David E Reuss^{1

2}, Martin Hasselblatt³, Christian Hagel⁴, Ori Staszewski⁵, Jürgen Hench⁶, Stephan Frank⁶, Sebastian Brandner^{7

8}, Andrey Korshunov^{1

2

9}, Wolfgang Wick^{10

11}, Stefan M Pfister^{9

12

13}, Guido Reifenberger^{14

15}, Andreas von Deimling^{1

2}, Felix Sahm^{16

17

18}, David T W Jones^{19

20}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Institute of Neuropathology, University Hospital Münster, Münster, Germany.
⁴ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
⁵ Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
⁶ Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
⁷ Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK.
⁸ Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
⁹ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
¹⁰ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
¹² Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹³ Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
¹⁴ Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
¹⁵ German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Germany.
¹⁶ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
¹⁷ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
¹⁸ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.
¹⁹ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. david.jones@dkfz.de.
²⁰ Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. david.jones@dkfz.de.

PMID: 31729570
DOI: 10.1007/s00401-019-02097-7

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Astrocytoma / genetics*
Astrocytoma / pathology*
Cohort Studies
DNA Methylation
Fetal Proteins / genetics
Gene Fusion / genetics*
Humans
Infratentorial Neoplasms / genetics*
Infratentorial Neoplasms / pathology
Microtubule-Associated Proteins / genetics
Mutation / genetics*
Nuclear Proteins / genetics
Oligodendroglia
Receptor, Fibroblast Growth Factor, Type 1 / genetics*

Substances

Fetal Proteins
Microtubule-Associated Proteins
Nuclear Proteins
TACC1 protein, human
FGFR1 protein, human
Receptor, Fibroblast Growth Factor, Type 1

Publication types

MeSH terms

Substances

Grants and funding