Binding partners of NRF2: Functions and regulatory mechanisms

Le Ba Nam; Young-Sam Keum

doi:10.1016/j.abb.2019.108184

Binding partners of NRF2: Functions and regulatory mechanisms

Arch Biochem Biophys. 2019 Dec 15:678:108184. doi: 10.1016/j.abb.2019.108184. Epub 2019 Nov 13.

Authors

Le Ba Nam¹, Young-Sam Keum²

Affiliations

¹ College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, South Korea.
² College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, South Korea. Electronic address: keum03@dongguk.edu.

PMID: 31733215
DOI: 10.1016/j.abb.2019.108184

Abstract

NRF2 is a redox-sensitive transcription factor that plays an important role in protecting organisms against diverse types of electrophiles or oxidants. The level of NRF2 is maintained low in normal cells, but highly elevated in cancer provoking chemoresistance or radioresistance. It is now recognized that NRF2 does not merely maintain the redox balance, but also plays significant roles in autophagy, apoptosis, cell cycle progression, and stem cell differentiation, all of which could be possibly attributable to the existence of multiple binding proteins. In the present manuscript, we summarize direct binding partners of NRF2 and illustrate how they bind to NRF2 and regulate its stability or activity.

Keywords: Antioxidant response element (ARE); Binding partners; NF-E2-related factor 2 (NRF2); NRF2-ECH homology (Neh) domains.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
NF-E2-Related Factor 2 / chemistry
NF-E2-Related Factor 2 / metabolism*
Protein Binding
Protein Domains

Substances

NF-E2-Related Factor 2