Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice

Genes Brain Behav. 2020 Jan;19(1):e12627. doi: 10.1111/gbb.12627. Epub 2019 Dec 14.

Abstract

The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission and known to mediate emotionality and male social behavior. However, a possible regulatory role in maternal behavior remains unknown to date. Adequate expression of maternal behavior is essential for successful rearing and healthy development of the young. By understanding genetic and neural mechanisms underlying this important prosocial behavior, we gain valuable insights into possible dysregulations. Using genetic ablation as well as pharmacological modulation, we studied various parameters of maternal behavior in two different mouse strains under the influence of mGlu7. We can clearly show a regulatory role of mGlu7 in maternal behavior. Naïve virgin female C57BL/6 mGlu7 knockout mice showed more often nursing postures and less spontaneous maternal aggression compared to their heterozygous and wildtype littermates. In lactating C57BL/6 wildtype mice, acute central activation of mGlu7 by the selective agonist AMN082 reduced arched back nursing and accelerated pup retrieval without affecting maternal aggression. In addition, in lactating CD1 wildtype mice the selective mGlu7 antagonist XAP044 increased both pup retrieval and maternal aggression. With respect to receptor expression levels, mGlu7 mRNA expression was higher in lactating vs virgin C57BL/6 mice in the prefrontal cortex, but not hypothalamus or hippocampus. In conclusion, these findings highlight a significant role of the mGlu7 receptor subtype in mediating maternal behavior in mice. Region-dependent studies are warranted to further extend our knowledge on the specific function of the brain glutamate system in maternal behavior.

Keywords: AMN082; XAP044; knockout; metabotropic glutamate receptor; social behavior; spontaneous maternal behavior; strain difference.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggression*
  • Animals
  • Benzhydryl Compounds / pharmacology
  • Chromones / pharmacology
  • Excitatory Amino Acid Agents / pharmacology
  • Female
  • Maternal Behavior*
  • Mice
  • Mice, Inbred C57BL
  • Motivation*
  • Prefrontal Cortex / drug effects
  • Prefrontal Cortex / metabolism
  • Receptors, Metabotropic Glutamate / agonists
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / genetics*
  • Receptors, Metabotropic Glutamate / metabolism

Substances

  • 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
  • Benzhydryl Compounds
  • Chromones
  • Excitatory Amino Acid Agents
  • N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor 7