Donor-specific antibodies in liver transplantation

Abstract

Despite unique immunoregulatory properties pointing toward tolerance, the liver allograft can be negatively impacted by humoral alloreactivity, with immediate as well as long-term harmful consequences. With regard to the unmet need of long-term outcomes improvement after liver transplantation, donor-specific antibodies have recently been the matter of intense study in this context. We review here recent advances regarding the understanding of the impact of preformed as well as de novo anti-human leukocyte antigen donor-specific antibodies in liver transplantation and discuss potential strategies to overcome this problem.

Keywords: AED; Alloreactivity; Alorreactividad; Antibody-mediated rejection; DSA; Ensayo en fase sólida; Immune tolerance; Inmunotolerancia; Liver transplantation; Rechazo mediado por anticuerpos; Solid-phase assay; Trasplante de hígado.