Tumour Dormancy and Reawakening: Opportunities and Challenges

Adrienne Boire; Seth B Coffelt; Sergio A Quezada; Matthew G Vander Heiden; Ashani T Weeraratna

doi:10.1016/j.trecan.2019.10.010

Tumour Dormancy and Reawakening: Opportunities and Challenges

Trends Cancer. 2019 Dec;5(12):762-765. doi: 10.1016/j.trecan.2019.10.010. Epub 2019 Nov 25.

Authors

Adrienne Boire¹, Seth B Coffelt², Sergio A Quezada³, Matthew G Vander Heiden⁴, Ashani T Weeraratna⁵

Affiliations

¹ Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Manhattan, NY 10065, USA. Electronic address: boirea@mskcc.org.
² Cancer Research UK Beatson Institute, Bearsden, Glasgow, G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Bearsden, Glasgow, G61 1QH, UK.
³ UCL Cancer Institute, University College London, Gower Street, London, WC1E 6BT, UK.
⁴ Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
⁵ Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.

PMID: 31813453
DOI: 10.1016/j.trecan.2019.10.010

Abstract

Tumour dormancy presents challenges for clinical control and opportunities for scientific discovery. Current pictures of the mechanisms of tumour dormancy and reawakening remain incomplete. The Cancer Research UK's third Marshall Symposium explored tumour dormancy and reawakening in all their forms. In this forum article, we highlight the key challenges and opportunities discussed at this symposium.

Keywords: advanced cancer; metastasis; relapse; secondary cancer; tumour dormancy; tumour reawakening.

Tumour Dormancy and Reawakening: Opportunities and Challenges

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