Impact of gut microbiota on neurogenesis and neurological diseases during infancy

Tomás Cerdó; Estefanía Diéguez; Cristina Campoy

doi:10.1016/j.coph.2019.11.006

Impact of gut microbiota on neurogenesis and neurological diseases during infancy

Curr Opin Pharmacol. 2020 Feb:50:33-37. doi: 10.1016/j.coph.2019.11.006. Epub 2019 Dec 18.

Authors

Tomás Cerdó¹, Estefanía Diéguez², Cristina Campoy³

Affiliations

¹ Department of Paediatrics, School of Medicine, University of Granada, Avda. De la Investigación 11, 18016 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain; BioHealth Research Institute (Ibs), Granada, Health Sciences Technological Park, 18016 Granada, Spain; Neurosciences Institute, Biomedical Research Centre, University of Granada, Spain.
² Department of Paediatrics, School of Medicine, University of Granada, Avda. De la Investigación 11, 18016 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain.
³ Department of Paediatrics, School of Medicine, University of Granada, Avda. De la Investigación 11, 18016 Granada, Spain; EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain; BioHealth Research Institute (Ibs), Granada, Health Sciences Technological Park, 18016 Granada, Spain; Neurosciences Institute, Biomedical Research Centre, University of Granada, Spain; Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada's node, Carlos III Health Institute of Health Carlos III, 28029 Madrid, Spain; Brain, Behavior and Health Excellence Research Unit, (SC2), University of Granada, Granada, Spain. Electronic address: ccampoy@ugr.es.

PMID: 31864102
DOI: 10.1016/j.coph.2019.11.006

Abstract

The first years of life constitute a crucial period for neurodevelopment and a window of opportunity to develop new strategies to prevent neurological and mental diseases. Different studies have shown the influence of gut bacteria in neurogenesis and a functional relationship between gut microbiota and the brain, known as 'gut-brain axis', in which the intestinal microbiota is proposed to play a key role in neurophysiological processes. It has been observed that certain microbiome metabolites could be related to the development of neurological disorders through mechanisms still unknown. Then, more studies are needed to broaden the knowledge regarding the relationship between the Central Nervous System and the gastrointestinal tract, which could help to develop new preventive and treatment protocols.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain*
Gastrointestinal Microbiome*
Humans
Infant, Newborn
Nervous System Diseases / microbiology*
Neurogenesis*