Magnetization transfer and frequency distribution effects in the SSFP ellipse

Tobias C Wood; Rui P A G Teixeira; Shaihan J Malik

doi:10.1002/mrm.28149

Magnetization transfer and frequency distribution effects in the SSFP ellipse

Magn Reson Med. 2020 Aug;84(2):857-865. doi: 10.1002/mrm.28149. Epub 2019 Dec 24.

Authors

Tobias C Wood¹, Rui P A G Teixeira², Shaihan J Malik²

Affiliations

¹ Department of Neuroimaging, King's College London, London, UK.
² School of Imaging Sciences and Biomedical Engineering, King's College London, London, UK.

Abstract

Purpose: To demonstrate that quantitative magnetization transfer (qMT) parameters can be extracted from steady-state free-precession (SSFP) data with no external T₁ map or banding artifacts.

Methods: SSFP images with multiple MT weightings were acquired and qMT parameters fitted with a two-stage elliptical signal model.

Results: Monte Carlo simulations and data from a 3T scanner indicated that most qMT parameters could be recovered with reasonable accuracy. Systematic deviations from theory were observed in white matter, consistent with previous literature on frequency distribution effects.

Conclusions: qMT parameters can be extracted from SSFP data alone, in a manner robust to banding artifacts, despite several confounds.

Keywords: MT; PLANET; SSFP.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Artifacts*
Magnetic Resonance Imaging*

Abstract

Publication types

MeSH terms

Grants and funding