Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report

Hirokazu Tokuyasu; Mika Horie; Soichiro Ishikawa; Hiromitsu Sakai; Hiroshi Miura; Akira Yamasaki

doi:10.1016/j.rmcr.2019.100976

Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report

Respir Med Case Rep. 2019 Dec 9:29:100976. doi: 10.1016/j.rmcr.2019.100976. eCollection 2020.

Authors

Hirokazu Tokuyasu¹, Mika Horie¹, Soichiro Ishikawa¹, Hiromitsu Sakai¹, Hiroshi Miura², Akira Yamasaki³

Affiliations

¹ Divisions of Respiratory Medicine, Matsue Red Cross Hospital, Shimane, Japan.
² Pathology, Matsue Red Cross Hospital, Shimane, Japan.
³ Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.

Abstract

We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal growth factor receptor (EGFR) exon 19 deletion in the lower lobe. Programmed death-1 (PD-1) inhibitors were administered as first-line chemotherapy; however, treatment response was poor response. There have been no reported SMPLC cases similar to this. During treatment, his non-smoking status and EGFR deletion might have been the cause of the patient's poor response to first-line PD-1 inhibitor treatment.

Keywords: Adenocarcinoma; Epidermal growth factor receptor; Programmed death-1 inhibitors; Programmed death-ligand 1; Squamous cell carcinoma; Synchronous multiple primary lung cancers.

Publication types

Case Reports