Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes

Org Lett. 2020 Jan 17;22(2):684-688. doi: 10.1021/acs.orglett.9b04459. Epub 2019 Dec 30.

Abstract

Iron-catalyzed hydrogen atom transfer-mediated intermolecular C-C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using Et3N, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope.