Patterns of Practice Survey: Radiotherapy for Soft Tissue Sarcoma of the Extremities

Chan-Kyung J Cho; Charles Catton; Caroline L Holloway; Karen Goddard

doi:10.7759/cureus.6153

Patterns of Practice Survey: Radiotherapy for Soft Tissue Sarcoma of the Extremities

Cureus. 2019 Nov 14;11(11):e6153. doi: 10.7759/cureus.6153.

Authors

Chan-Kyung J Cho¹, Charles Catton², Caroline L Holloway³, Karen Goddard⁴

Affiliations

¹ Surgery, University of British Columbia, Vancouver, CAN.
² Radiation Oncology, Princess Margaret Hospital / University of Toronto, Toronto, CAN.
³ Radiation Oncology, British Columbia Cancer Agency, Victoria Centre, University of British Columbia, Victoria, CAN.
⁴ Radiation Oncology, British Columbia Cancer Agency, Vancouver Centre, University of British Columbia, Vancouver, CAN.

Abstract

Background Neoadjuvant or adjuvant radiotherapy (RT) for extremity soft tissue sarcoma (STS) confers significant local control benefit. To determine patterns of practice, a survey of RT planning practices was undertaken. Method Members of the Connective Tissue Oncology Society and Canadian Association of Radiation Oncology participated in this survey pertaining to general practice patterns of RT for extremity STS, patterns of contouring and planning, and use of quality control measures such as guidelines, tumor boards, and quality assurance rounds. Results A total of 58 radiation oncologists treating extremity STS from 12 countries responded. 89.7% work in academically affiliated centres, and 55.2% saw at least 20 cases of extremity STS per year. Most (96.7%) had access to multidisciplinary sarcoma boards (85.5% of those discussed every referred sarcoma case). 78.6% held quality assurance rounds. Most (92.9%) used planning guidelines. Pre-operative RT was used nearly twice as much as post-operative RT. CT simulation with MR fusion was used by 94.6%. Patterns of clinical target volume (CTV) contouring for both superficial and deep STS were variable. 69.8% contoured a normal soft tissue strip for extremity sarcoma, 13.5% without routine constraints and the remainder with various constraints. Most (91.1%) used 50 Gy in 25 fractions pre-operatively and 39.6% reported using post-operative RT boost for positive margins. Post-operative dose was more variable from 59.4 Gy to 70 Gy. Conclusion Major aspects of RT planning for extremity STS were similar among the responders, and most were academically affiliated. Over twice as many employed pre-operative as opposed to post-operative RT. There was considerable heterogeneity in use of: margins for contouring, normal soft tissue strip as an avoidance structure, and boost for positive margins. This survey shows variable patterns of practice and identifies areas that may require further research.

Keywords: patterns of practice; radiotherapy for sarcoma; sarcoma; soft tissue sarcoma of the extremities.