Hematological malignancies in connective tissue diseases

Lupus. 2020 Mar;29(3):225-235. doi: 10.1177/0961203319899986. Epub 2020 Jan 14.

Abstract

Chronic inflammation has profound tumor-promoting effects. Inflammatory cells are the key players in immunosurveillance against tumors, and immunosuppression is known to increase the risk of tumors. Autoimmune diseases, which manifest as loss of self-tolerance and chronic immune dysregulation, provide a perfect environment for tumor development. Aside from managing the direct inflammatory consequences of autoimmune pathogenesis, cancer risk profiles should be considered as a part of a patient's treatment. In this review, we describe the various associations of malignancies with autoimmune diseases, specifically systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and Sjögren's syndrome, as well as discuss the mechanisms contributing to the pathogenesis of both disorders.

Keywords: Hematological malignancies; Sjögren's syndrome; inflammation; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / complications
  • Connective Tissue Diseases / complications*
  • Connective Tissue Diseases / physiopathology
  • Hematologic Neoplasms / etiology*
  • Hematologic Neoplasms / physiopathology
  • Humans
  • Inflammation / complications
  • Inflammation / physiopathology
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / physiopathology
  • Rheumatic Diseases / complications
  • Rheumatic Diseases / physiopathology
  • Risk Factors
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / physiopathology
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / physiopathology