Prostate-specific Membrane Antigen-expressing Hepatic Lesion: Metastatic or Hepatocellular Carcinoma

Jayanta Das; Soumendranath Ray; Rohit Tapadia; Divya Midha; Indranil Mallick

doi:10.4103/ijnm.IJNM_145_19

Prostate-specific Membrane Antigen-expressing Hepatic Lesion: Metastatic or Hepatocellular Carcinoma

Indian J Nucl Med. 2020 Jan-Mar;35(1):58-60. doi: 10.4103/ijnm.IJNM_145_19. Epub 2019 Dec 31.

Authors

Jayanta Das¹, Soumendranath Ray¹, Rohit Tapadia², Divya Midha², Indranil Mallick³

Affiliations

¹ Department of Nuclear Medicine and PET-CT, Tata Medical Center, Kolkata, West Bengal, India.
² Department of Oncopathology, Tata Medical Center, Kolkata, West Bengal, India.
³ Department of Radiation Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Abstract

Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. It has emerged as a novel radiotracer for evaluation of prostate cancer. Increased PSMA expression in isolated liver lesion is a diagnostic challenge. Solitary liver metastasis from prostate cancer is rare. On the other hand, PSMA avid primary hepatocellular carcinoma (HCC) has been reported in literature. We report a case of PSMA expressing atypical HCC with normal alphafeto protein (AFP) and raised prostate specific antigen (PSA).

Keywords: Hepatocellular carcinoma; prostate cancer; prostate-specific membrane antigen; solitary liver lesion.

Publication types

Case Reports