αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

Affiliations

• ¹ Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
• ² Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, No 135 12, 30107, Guadalupe, Spain.
• ³ Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, 02115, USA.
• ⁴ Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
• ⁵ Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
• ⁶ Hospital Clinic of Barcelona, Career Villarroel, 170, 08036, Barcelona, Spain.
• ⁷ Department of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain.
• ⁸ Department of Traumatology and Research Unit, Clinica CEMTRO, 28035, Madrid, Spain. pedroguillen612@gmail.com.
• ⁹ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ibp.ac.cn.
• ¹⁰ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ibp.ac.cn.
• ¹¹ Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ibp.ac.cn.
• ¹² Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. ghliu@ibp.ac.cn.
• ¹³ Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. belmonte@salk.edu.