Comparison of Sound Touch Elastography, Shear Wave Elastography and Vibration-Controlled Transient Elastography in Chronic Liver Disease Assessment using Liver Biopsy as the "Reference Standard"

Abstract

Chronic liver disease (CLD) is currently a major cause of death. Ultrasound elastography (USE) is an imaging method that has been developed for CLD assessment. Our aim in the study described here was to evaluate and compare a new commercial variant of USE, sound touch elastography (STE), with already established USE methods, shear wave elastography (SWE) and vibration-controlled transient elastography (VCTE), using liver biopsy as the "reference standard." For our study, 139 consecutive patients underwent standard liver STE, SWE and VCTE examinations with the corresponding ultrasound devices. A receiver operator characteristic (ROC) curve analysis was performed on the stiffness values measured with each method. ROC analysis revealed, for SWE, STE and VCTE, areas under the ROC curve of 0.9397, 0.9224 and 0.9348 for fibrosis stage (F), F ≥ F1; 0.9481, 0.9346 and 0.9415 for F ≥ F2; 0.9623, 0.9591 and 0.9631 for F ≥ F3; and 0.9581, 0.9541 and 0.9632 for F = F4, respectively. In conclusion, STE performs similarly to SWE and VCTE in CLD stage differentiation.

Keywords: Chronic liver disease; Fibrosis; Shear wave elastography; Sound touch elastography; Vibration-controlled transient elastography.