Dataset on the prognostic value of cardiac biomarkers used in clinical routine in patients with severe aortic stenosis undergoing valve replacement

Fabian Barbieri; Thomas Senoner; Agne Adukauskaite; Stephan Dobner; Johannes Holfeld; Severin Semsroth; Thomas Lambert; David Zweiker; Thomas Theurl; Peter Rainer; Albrecht Schmidt; Gudrun Feuchtner; Clemens Steinwender; Uta Hoppe; Florian Hintringer; Axel Bauer; Silvana Müller; Michael Grimm; Bernhard Pfeifer; Wolfgang Dichtl

doi:10.1016/j.dib.2020.105111

Dataset on the prognostic value of cardiac biomarkers used in clinical routine in patients with severe aortic stenosis undergoing valve replacement

Data Brief. 2020 Jan 9:29:105111. doi: 10.1016/j.dib.2020.105111. eCollection 2020 Apr.

Authors

Fabian Barbieri¹, Thomas Senoner¹, Agne Adukauskaite¹, Stephan Dobner², Johannes Holfeld³, Severin Semsroth³, Thomas Lambert⁴, David Zweiker⁵, Thomas Theurl⁶, Peter Rainer⁵, Albrecht Schmidt⁵, Gudrun Feuchtner⁷, Clemens Steinwender⁴, Uta Hoppe⁶, Florian Hintringer¹, Axel Bauer¹, Silvana Müller¹, Michael Grimm³, Bernhard Pfeifer^{8

9}, Wolfgang Dichtl¹

Affiliations

¹ University Clinic of Internal Medicine III, Medical University Innsbruck, Innsbruck, Austria.
² Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
³ University Clinic of Heart Surgery, Medical University Innsbruck, Innsbruck, Austria.
⁴ Department of Cardiology, Kepler University Hospital, Medical Faculty, Johannes Kepler University Linz, Austria.
⁵ Department of Internal Medicine, Division of Cardiology, Medical University Graz, Graz, Austria.
⁶ University Clinic of Internal Medicine II, Paracelsus Medical University, Salzburg, Austria.
⁷ University Clinic of Radiology, Medical University Innsbruck, Innsbruck, Austria.
⁸ Institute of Clinical Epidemiology, Tirol Kliniken, Innsbruck, Austria.
⁹ Institute of Electrical and Biomedical Engineering, University for Health Sciences, Medical Informatics and Technology (UMIT), Hall in Tirol, Austria.

Abstract

Hereby, the supplemental data of the research article "Long-Term Prognostic Value of High-Sensitivity Troponin T added to N-Terminal Pro Brain Natriuretic Peptide Plasma Levels before Valve Replacement for Severe Aortic Stenosis" are presented [1]. It offers enhanced input on the predictive value of these biomarkers considering the influence of the presence of concomitant coronary artery disease (CAD) in various severities as well as an additional cox proportional hazard model on cardiovascular mortality. Furthermore, the receiver operating characteristic (ROC) curves are shown as figures. The material described increases therefore the understanding of the predictive value of these already routinely available biomarkers and reduces the risk of potential bias due to possible confounding factors. It also underlines the urge for a multi-factorial approach in diagnostics to detect the optimal point for referral to valve replacement other than just symptomatic status, an observed reduction in left ventricular ejection fraction or the presence of CAD with the necessity for coronary artery bypass grafting (CABG) [2]. The data of the 3595 patients were gathered retrospectively at a consortium of four university hospital centers in Austria and combined with prospectively collected data on cardiovascular and all-cause mortality.

Keywords: High sensitivity troponin T; N-terminal pro brain natiuretic peptide; Risk stratification; Severe aortic stenosis; Survival; Valve replacement.