Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature

Lisa M Cordes; Nicole N Davarpanah; Lauren B Reoma; Billel Gasmi; Martha Quezado; Omar I Khan; Avindra Nath; Andrea B Apolo

doi:10.1002/ccr3.2534

Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature

Clin Case Rep. 2019 Nov 26;8(1):24-32. doi: 10.1002/ccr3.2534. eCollection 2020 Jan.

Authors

Lisa M Cordes^{1

2}, Nicole N Davarpanah¹, Lauren B Reoma³, Billel Gasmi⁴, Martha Quezado⁴, Omar I Khan³, Avindra Nath³, Andrea B Apolo¹

Affiliations

¹ Genitourinary Malignancies Branch National Cancer Institute National Institutes of Health Bethesda Maryland.
² Office of Clinical Research Office of the Director National Institutes of Health Bethesda Maryland.
³ National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland.
⁴ Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda Maryland.

Abstract

We report a case of nivolumab-induced delayed-onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.

Keywords: aseptic meningitis; checkpoint inhibitor; encephalitis; ipilimumab; neurotoxicity; nivolumab.

Published 2019. This article is a U.S. Government work and is in the public domain in the USA.

Publication types

Case Reports