Genetic Polymorphisms and Forensic Efficiencies of a Set of Novel Autosomal InDel Markers in a Chinese Mongolian Group

Wenqing Zhang; Xiaoye Jin; Yijie Wang; Tingting Kong; Wei Cui; Chong Chen; Yuxin Guo; Bofeng Zhu

doi:10.1155/2020/3925189

Genetic Polymorphisms and Forensic Efficiencies of a Set of Novel Autosomal InDel Markers in a Chinese Mongolian Group

Biomed Res Int. 2020 Jan 8:2020:3925189. doi: 10.1155/2020/3925189. eCollection 2020.

Authors

Wenqing Zhang^{1

2}, Xiaoye Jin^{1

2

3}, Yijie Wang^{1

2}, Tingting Kong^{1

2}, Wei Cui^{1

2

3}, Chong Chen^{1

2

3}, Yuxin Guo^{1

2

3}, Bofeng Zhu^{1

2

4}

Affiliations

¹ Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
² Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
³ College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, China.
⁴ Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Abstract

Insertion/deletion (InDel) markers have been treated as a prospective and helpful aid in the fields of forensic human identifications and biogeography origin researches for the past few years. In this study, we analyzed genetic polymorphisms and forensic efficiencies of 35 InDels in a novel multiplex PCR-InDel panel in a Chinese Mongolian group. All these 35 InDel loci were observed to conform to Hardy-Weinberg equilibrium and linkage equilibrium. The mean values of expected heterozygosity and observed heterozygosity were 0.4788 and 0.4852, respectively. Besides, the interpopulation differentiations and genetic distributions based on 35 InDels found that the Chinese Mongolian group might have closer genetic relationships and similar population genetic structures with East Asian populations.

Publication types

Clinical Trial

MeSH terms

Asian People* / ethnology
Asian People* / genetics
China / ethnology
Female
Genetic Markers
Humans
INDEL Mutation*
Male
Multiplex Polymerase Chain Reaction
Polymorphism, Genetic*

Substances

Genetic Markers