Achieving Opioid-Free Major Colorectal Surgery: Is It Possible?

Dig Surg. 2020;37(5):376-382. doi: 10.1159/000505516. Epub 2020 Jan 30.

Abstract

Introduction: Opioid analgesia remains the mainstay of postoperative pain management strategies despite being associated with many adverse effects. A specific opioid-free protocol was designed to limit opioid usage.

Objective: The aim of the study was to audit the opioid-free rate within this protocol and to identify factors that might contribute to opioid-free surgery.

Methods: A retrospective study of all elective patients receiving abdominal colorectal surgery at the Center for Colon and Rectal Surgery at AdventHealth over 6 months was performed. Data on demographics, indications, perioperative management, outcomes, and inpatient and outpatient analgesic requirements were collected with subsequent analysis.

Results: A total of 303 consecutive patient records were analyzed. Approximately two-thirds (67.7%) of patients did not receive narcotics once they left the postanesthesia care unit as an inpatient. One-third of patients (32.0%) did not receive narcotic analgesia within 30 days of surgery as an outpatient. Patients in the opioid-free cohort were significantly older and had a malignant indication, less perioperative morbidity, and a shorter length of stay.

Conclusions: Our study demonstrates that opioid-free analgesia is indeed possible in major colorectal surgery. Study limitations include its retrospective nature and that it is from a single institution. Despite these limitations, this study provides proof of concept that opioid-free colorectal surgery is possible within a specific protocol.

Keywords: Colorectal surgery; Enhanced recovery after surgery; Opioid-free surgery; Perioperative outcomes.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Analgesics, Non-Narcotic / therapeutic use
  • Analgesics, Opioid / therapeutic use*
  • Colon / surgery*
  • Enhanced Recovery After Surgery*
  • Female
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Pain Management / methods
  • Pain, Postoperative / etiology
  • Pain, Postoperative / prevention & control*
  • Rectum / surgery*
  • Retrospective Studies
  • Young Adult

Substances

  • Analgesics, Non-Narcotic
  • Analgesics, Opioid