First Case of 2019 Novel Coronavirus in the United States

N Engl J Med. 2020 Mar 5;382(10):929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31.

Abstract

An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient's initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Betacoronavirus / genetics*
  • Betacoronavirus / isolation & purification
  • Blood Chemical Analysis
  • COVID-19
  • COVID-19 Testing
  • China
  • Clinical Laboratory Techniques
  • Coronavirus Infections* / diagnosis
  • Coronavirus Infections* / therapy
  • Coronavirus Infections* / transmission
  • Disease Progression
  • Genome, Viral
  • Humans
  • Lung / diagnostic imaging*
  • Lung / pathology
  • Male
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / therapy
  • Pneumonia, Viral* / transmission
  • Radiography, Thoracic
  • SARS-CoV-2
  • Sequence Analysis, DNA
  • Travel
  • United States