The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment

Ramin Salehi-Rad; Rui Li; Manash K Paul; Steven M Dubinett; Bin Liu

doi:10.1016/j.ccm.2019.10.003

The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment

Clin Chest Med. 2020 Mar;41(1):25-38. doi: 10.1016/j.ccm.2019.10.003.

Authors

Ramin Salehi-Rad¹, Rui Li², Manash K Paul², Steven M Dubinett³, Bin Liu⁴

Affiliations

¹ Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 43-22 CHS, Los Angeles, CA 90095-1690, USA; Department of Medicine, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.
² Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 43-22 CHS, Los Angeles, CA 90095-1690, USA.
³ Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 43-22 CHS, Los Angeles, CA 90095-1690, USA; Department of Medicine, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, 8-684 Factor Building, Box 951781, Los Angeles, CA 90095-1781, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 650 Charles E Young Dr S, 23-120 CHS, Los Angeles, CA 90095, USA. Electronic address: SDubinett@mednet.ucla.edu.
⁴ Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, 43-22 CHS, Los Angeles, CA 90095-1690, USA. Electronic address: bliu@mednet.ucla.edu.

PMID: 32008627
DOI: 10.1016/j.ccm.2019.10.003

Abstract

Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.

Keywords: Biology of lung cancer; Genomic alterations; Immunotherapy; Lung cancer early detection; Lung cancer prevention; NSCLC and SCLC; Targeted therapy; Tumor microenvironment.

Publication types

Review

MeSH terms

Humans
Immunotherapy / methods*
Lung Neoplasms / diagnosis*
Lung Neoplasms / prevention & control*
Lung Neoplasms / therapy*