Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations

Makrina Karaglani; Evmorfia Tzitzikou; Stylianos Tottas; Ioannis Kougioumtzis; Konstantinos Arvanitidis; George Kolios; Ekaterini Chatzaki; Georgios I Drosos

doi:10.1016/j.jor.2019.11.034

Gentamycin elution from polymethylmethacrylate and bone graft substitute: Comparison between commercially available and home-made preparations

J Orthop. 2019 Nov 27:19:9-13. doi: 10.1016/j.jor.2019.11.034. eCollection 2020 May-Jun.

Authors

Makrina Karaglani¹, Evmorfia Tzitzikou¹, Stylianos Tottas², Ioannis Kougioumtzis², Konstantinos Arvanitidis¹, George Kolios¹, Ekaterini Chatzaki¹, Georgios I Drosos²

Affiliations

¹ Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
² Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Greece.

Abstract

Polymethylmethacrylate (PMMA) represents the current gold standard as an antibiotic delivery carrier in orthopaedic surgery. Despite the accepted use of local antibiotic carriers, there aren't any conclusive data comparing PMMA to Bone Graft Substitutes. The aim of this in vitro study was to compare the elution profile of gentamicin from various preparations of PMMA cements and Herafill beads. All cements had high initial elution during the first hour which then slowly decreased, Herafill beads on the other hand showed its higher elution around the eighth hour. Herafill, in general, presented the highest elution of gentamicin regardless of its input amount.

Keywords: Copal; Gentamicin; Herafill; In vitro release; PMMA; Palacos.